School of Science, Health and Technology
Biology Department
Anthony Udeogalanya, Chairperson
tel. 718.270.6213

 

 

Alam Nur-E-Kamal

Associate Professor of Biology


 Ph.D., Molecular Biology,

University of Tokyo, Japan, 1989

 

 


 

 SELECTED PUBLICATIONS:

1.  Holden, J. L., Nur-E-Kamal, A., Fabri, L., Nice, E., Hammacher, A., and Maruta, H. Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation.  J. Biol. Chem. 266:16992-16995, 1991.

2.  Nur-E-Kamal, A. and Maruta, H. (1991). Ras and Rap1 GTPases mutated at position 64. Ras superfamily (Spandidos, D. A. Ed. ) New York, Plenum Publishing Co. pp. 105-110.

3.  Nur-E-Kamal, A., Sizeland, A., D'Abaco, G., and Maruta, H. Asparagine 26, glutamic acid 31, valine 45, and tyrosine 64 of Ras proteins are required for their oncogenicity.  J. Biol. Chem. 267:1415-1418, 1992.

4.  Nur-E-Kamal, A. and Maruta, H. The role of Gln61 and Glu63 of Ras GTPases in their activation by NF1 and Ras GAP.  Mol. Biol. Cell 3:1437-1442, 1992.

5.  Maruta, H., Bartlett, P. F., Nurcombe, V., Nur-E-Kamal, A., Chomienne, C., Muramatsu, T., Muramatsu, H., Fabri, L., Nice, E., and Burgess, A. W. Midkine (MK), a retinoic acid (RA)-inducible gene product, produced in E. coli acts on neuronal and HL60 leukemia cells.  Growth Factors. 8:119-134, 1993.

6.  Morii, N.*, Kumagai, N.*, Nur-E-Kamal, A.*, Narumiya, S., and Maruta, H. rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190), requires Asp65 and Asp67 of rho GTPase for its activation.  J. Biol. Chem. 268:27160-27163, 1993.

7.  Nur-E-Kamal, A., Varga, M., and Maruta, H. The GTPase-activating NF1 fragment of 91 amino acids reverses v-Ha-Ras- induced malignant phenotype.  J. Biol. Chem. 268:22331-22337, 1993.

8.  Fridman, M., Tikoo, A., Varga, M., Murphy, A., Nur-E-Kamal, A. and Maruta, H. The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras- induced malignant phenotype.  J. Biol. Chem. 269:30105-30108, 1994.

9.  Nur-E-Kamal, A., al Mamun, A. A., and Ahmed, Z. U. Molecular cloning of the wild-type and mutant thyA gene from Shigella flexneri Y.  Microbiol. Immunol. 38:309-312, 1994.

10. Hattori, M., Tsukamoto, N., Nur-E-Kamal, A., Rubinfeld, B., Iwai, K., Kubota, H., Maruta, H., and Minato, N. Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression.  Mol. Cell Biol. 15:552-560, 1995.

11. Nur-E-Kamal, A. Overexpression and functional analysis of a mitogen-inducible nuclear GTPase activating protein, Spa-1.  Int. J. Biochem. Cell Biol. 28:1241-1247, 1996.

12. Maruta, H. and Nur-E-Kamal, A. NF1 (neurofibromatosis type 1).  Gan. To. Kagaku. Ryoho. 24:1422-1426, 1997.

13. Nur-E-Kamal, A., Reverey, H., Ponimaskin, E., Schroth-Diez, B., Herrmann, A., and Schmidt, M. F. Targeted delivery of human neurofibromin and c-Raf-1 mutants to the cytoplasmic membrane by use of the influenza virus hemagglutinin.  Biochim. Biophys. Acta 1338:233-243, 1997.

14. Wang, D. Z., Nur-E-Kamal, A., Tikoo, A., Montague, W., and Maruta, H. The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors.  Cancer Res 57:2478-2484, 1997.

15. Nur-E-Kamal, A., Raza, H., Qureshi, M., Jaffer, U. and Ijaz, M. K. Differential expression and characterization of proto-oncogene product Ha-Ras GTPase in camel tissues. Int. J. Oncol. 11:47-52. 1997.

16. Maruta, H., He, H., Tikoo, A., Vuong ,T. And Nur‑E‑Kamal A. G proteins, phosphoinositides, and actin‑cytoskeleton in the control of cancer growth. Microsc. Res. Tech. 47' 61‑6, 1999.

17. Meiners, S., Mercado, M., Nur-E-Kamal, A. and Geller, H.M. Tenascin-C contains domains that independently regulate neurite outgrowth and neurite guidance.  J.  Neeurosci.  19, 8443-8453, 1999.

18. Nur-E-Kamal, A., Kamal, J.M., Qureshi, M.M. and Maruta, H. The Cdc42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation. Oncogene 18, 7787 ‑ 7793, 1999.

19. Nur‑E‑Kamal, A., Qureshi, M.M., Kamal, J.M., Montague, W. and Maruta, H. Construction of a cell‑permeable CDC42 binding fragment of ACK that inhibits v‑Ha‑Ras transformation. Ann N. Y. Acad. Sci. 886:285‑8, 1999.

20. Maruta, H., He, H., Tikoo, A., Nur‑E‑Kamal A. Cytoskeletal tumor suppressors that block oncogenic RAS signaling. Ann. N.Y. Acad. Sci. 886:48‑57, 1999.

21. Nur-E-Kamal, A., Qureshi, M. M., Ijaz, M.K. and Raza, H. Proto-oncogene Ras GTPase-linked induction of glutathione-S-transferase by growth factors in PC12 cells. Int. J. Oncol 16:1043-8, 2000.

22. Begum, R., Zaman, M.A. and Nur-E-Kamal, A. Serum-dependent perinuclear accumulation  of Cdc42 in mammalian cells. Oncol. Rep. 8, 71-76, 2001.

23. Sachdev, P., Xiang-Jiang, YI, Li, W., Miki, T., Maruta, H., Nur-E-Kamal, A. and Wang, L. Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation. J Biol Chem 276: 26461-71 (2001).

24. Bayoumi, R, Saar, K, Lee, YA, Nurnberg, G, Reis, A, Nur-E-Kamal, A. and Al-Gazali LI  Localisation of a gene for an autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia, and distinctive facies to chromosome 15q26. J Med Genet  38:369-73 (2001)  .

25. Meiners, S., Nur-E-Kamal, A. and Mercado, M.L.T. Identification of a neurite outgrowth-promoting motif within the alternatively spliced region of human tenascin-C. J. Neurosci. 21: 7215-25 (2001).

26.  Nur-E-Kamal, A, Li, Tsai-Kun, Zhang, A., Qi, H., Pars, E. and Liu, L. F.  Single-stranded DNA induces ATM/p53-dependent DNA damage and apoptosis signals. J. Biol. Chem. 278:12475-81 (2003).

27.  Qi, H., Li, TK., Kuo, D., Nur-E-Kamal, A. and Liu, L.F. Inactivation of Cdc13p triggers MEC1 dependent apoptotic signals in yeast. J. Biol. Chem. 278: 15136-41 (2003).

28. Zhou, N., Xiao, H., Li, T.K., Nur-E-Kamal, A. and Liu, L.F. DNA damage-mediated apoptosis induced by selenium compounds. J. Biol. Chem. 278 :29532-7 (2003).

29. Ahmed, I., Calle, Y., Sayed, M.A., Kamal, J.M., Rengaswamy, P., Manser, E., Meiners, S. and Nur-E-Kamal, A. Cdc42-dependent nuclear translocation of non-Receptor tyrosine kinase, ACK. Biochem. Biophys. Res. Comm. 314, 571-579(2004).

30.  Mercado, M.L.T.*, Nur-E-Kamal, A.*, Liu, H*., Gross, S.*, Reza, M. and Meiners, S. Neurite outgrowth by the alternatively spliced region of human tenascin-c is mediated by the neuronal α7β1 integrin. J. Neurosci., 24, 238-47(2004).

31.  Nur-E-Kamal, A., Gross, S., Pan, Z., Balklava, Z., Ma, J. and Liu, L.F. Nuclear translocation of cytochrome C during apoptosis. J. Biol. Chem. 279, 24911-24914 (2004).

32.  Begum, R., Nur-E-Kamal, A., and Zaman, M.A. The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement.
Exp Mol Med. 36:358-66, 2004.

33.  Schindler, M., Ahmed, I., Kamal, J., Nur-E-Kamal, A., Grafe, T, Chung, H., and Meiners S.  A Synthetic Extracellular Matrix Promotes In Vivo-like Organization and Morphogenesis for Cells in Culture. Biomaterial 26:5624-31, 2005.

34.  Nur-E-Kamal, A., Zhang, A. Keenan, S. Seraj, J. Satoh, T. and Welsh, W. Requirement of Activated Cdc42-Associated Kinase (ACK) for Survival of v-Ras-Transformed Mammalian Cells. Mol Cancer Res. 3:297-305, 2005.

35.  Nur-E-Kamal, A., Ahmed, I., Kamal, J., Schindler, M., and Meiners S. Three dimensional nanofibrillar surfaces induce activation of Rac. Biochem Biophys Res Commun. 331:428-34, 2005.

36.  Liu, H.Y., Nur-E-Kamal, A., Schachner, M., and Meiners, S. Neurite guidance by the FnC repeat of human tenascin-C: neurite attraction vs. neurite retention. Eur J Neurosci. 22:1863-72, 2005.

37.  Ahmed, I., Calle, Y., Iwashita, S., and Nur-E-Kamal, A. Role of Cdc42 in neurite outgrowth of PC12 cells and cerebellar granule neurons. Mol Cell Biochem. 281:17-25, 2006.

38.  Desai, S.D., Haas, A.L., Wood, L.M., Pestka, S., Rubin, E.H., Saleem, A., Nur-E-Kamal, A., and Liu, L.F. Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res. 66:921-8, 2006.

39.  Nur-E-Kamal, A., Ahmed, I., Kamal, J., Schindler, M and Meiners, S. Three-dimensional nanofibrillar surfaces promote self-renewal in mouse embryonic stem cells. Stem Cells. 24:426-33, 2006.